High serum concentration of selenium,but not calcium,cobalt, copper,iron, and magnesium,increased the risk of both hyperglycemia and dyslipidemia in adults: A health examination center based cross-sectional study |
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| Institution: | 1. School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, 518100, China;2. Institute of Laboratory Medicine, Shenzhen Center for Chronic Disease Control, Shenzhen, 518020, China;3. Physicochemical Laboratory, Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China;4. Shenzhen Qilinshan Sanatorium, Shenzhen, 518055, China;5. Guangdong Province Engineering Laboratory for Nutrition Translation, Guangzhou, 510080, China;1. Russian Society of Trace Elements in Medicine, ANO “Centre for Biotic Medicine”, Zemlyanoy Val St. 46, Moscow 105064, Russia;2. RUDN University, Miklukho-Maklay St., 10/2, Moscow 117198, Russia;3. All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, Moscow 117216, Russia;4. Orenburg State University, Pobedy Avenue, 13, 460018 Orenburg, Russia;5. Orenburg State Medical University, Sovetskaya St., 6, Orenburg 460000, Russia;6. Yaroslavl State University, Sovetskaya St., 14, Yaroslavl 150000, Russia;1. Division of Endocrinology and Metabolism, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea;2. Department of Internal Medicine, Graduate School, Hanyang University, Seoul, South Korea;3. Department of Internal Medicine, CM Hospital, Seoul, South Korea;4. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea;5. Department of Clinical Nutrition, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea;6. Department of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea;1. Department of Emergency, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;2. Department of Endocrine and Metabolic Diseases, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;3. Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;1. Department of Endocrinology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. Ministry of Education-Shanghai Key Laboratory of Children''s Environmental Health, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China |
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| Abstract: | BackgroundMetabolic disorders of glucose and lipid were associated with some mineral elements, and data were warranted from various contexts to make the association more explicit.ObjectiveTo investigate the relationships between the serum concentrations of six mineral elements (calcium, cobalt, copper, iron, magnesium, and selenium) and the risk of hyperglycemia and dyslipidemia in adults.MethodsThe basic information and the over-night fasting serum samples of adults were randomly collected at a health examination center. The serum concentrations of glucose and lipids were measured with an automatic biochemical analyzer, and the mineral elements were measured with an inductively coupled plasma mass spectrometer. Data were analyzed between the hyperglycemia group (HGg) and the normal glucose group (NGg) as well as between the dyslipidemia group (DLg) and the normal lipid group (NLg).ResultsA total of 1466 adults aged 22–81 years (male/female = 1.8) were included, 110 in the HGg and 1356 in the NGg, or 873 in the DLg and 593 in the NLg. The serum element concentration medians P50 (P25–P75)] significantly different between the HGg and the NGg were 0.83 (0.75–0.94) vs. 0.76 (0.68–0.87) mg/L for copper and 100 (90–110) vs. 94 (87–103) μg/L for selenium (P < 0.001), while those between the DLg and the NLg were 99 (92–110) vs. 97 (90–106) mg/L for calcium, 0.78 (0.69–0.88) vs. 0.75 (0.66–0.85) mg/L for copper, 1.7 (1.4–2.0) vs. 1.6 (1.3–2.0) mg/L for iron, 24 (22–28) vs. 23 (22–27) mg/L for magnesium, and 97 (89–106) vs. 92 (84–100) μg/L for selenium (P < 0.05). When the copper and selenium between the HGg and the NGg were analyzed by logistic regression with age, gender, body mass index, and mineral elements adjusted, only the highest quartile of selenium concentration had association with the increased risk of hyperglycemia quartile (Q) 4 against Q1: OR = 2.9, 95 % CI = 1.5–5.5, P < 0.001). When the five differed mineral elements between the DLg and the NLg were similarly analyzed, only iron and selenium had associations with the increased risk of dyslipidemia (e.g., Q4 against Q1: OR = 1.4, 95 % CI = 1.1–2.0 for iron and OR = 2.9, 95 % CI = 2.1–4.0 for selenium, P < 0.05).ConclusionIn contrast to those of calcium, cobalt, copper, iron, and magnesium, the higher serum concentration of selenium increased the risk of both hyperglycemia and dyslipidemia in the study population of adult Chinese. |
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| Keywords: | Glucose Lipids Hyperglycemia Dyslipidemia Selenium Mineral element |
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