Association of iron levels in hair with brain structures and functions in young adults |
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| Institution: | 2. Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan;3. Institute of Development, Aging and Cancer, Department of Geriatrics and Gerontology, Tohoku University, Sendai, Japan;4. Department of Social Pharmacy and Public Health, Showa Pharmaceutical University, Tokyo, Japan;6. Physical Medicine and Rehabilitation, Tohoku University Hospital, Sendai, Japan;5. Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan;11. Department of Medical Informatics, Tohoku University Graduate School of Medicine, Sendai, Japan;12. Department of Community Medical Support, Tohoku University, Sendai, Japan;8. Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Aichi, Japan;10. Tohoku Medical Megabank organization, Tohoku University, Sendai, Japan |
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| Abstract: | BackgroundIron plays a critical role in normal brain functions and development, but it has also been known to have adverse neurological effects.MethodsHere, we investigated the associations of iron levels in hair with regional gray matter volume (rGMV), regional cerebral blood flow (rCBF), fractional anisotropy (FA), mean diffusivity (MD), and cognitive differences in a study cohort of 590 healthy young adults.ResultsOur findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe.ConclusionThese results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults. |
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| Keywords: | Hair minerals Iron Regional gray matter volume Hippocampus Diffusion tensor imaging Perfusion |
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