Association of twenty-three plasma elements with fasting serum glucose among Chinese population from four areas with different pollution level |
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| Institution: | 1. Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, 410078, China;2. Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, 410013, China;3. Environmental Science and Engineering, College of Resource and Environment, Hunan Agricultural University, Changsha, 410128, China;4. Department of Occupational and Environmental Health, Huazhong University of Science and Technology, Wuhan, 430030, China;5. Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, 410078, China;6. Hunan Occupational Disease Prevention and Control Institute, Changsha, 410007, China;7. Public Health College, Kunming Medical University, Kunming, 650500, China;8. Center for Environment and Health in Water Source Area of South-to-North Water Diversion, Hubei University of Medicine, Shiyan, 442000, China;9. Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China;1. Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy;2. Department of Biomedical Sciences—Histology, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy;3. Department of Medical Surgical and Experimental Sciences, Ophthalmology Unit, University of Sassari, Viale San Pietro 43/C, 07100 Sassari, Italy;4. I.S.R.C.T.––International Society for Research on Cadmium Toxicity, Viale San Pietro 43/B, 07100 Sassari, Italy;1. Department of Occupational Health, School of Public Health, Shanxi Medical University, China;2. Key Lab of Environmental Hazard and Health of Shanxi Province, Shanxi Medical University, China;3. Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, China;4. Sixth Hospital of Shanxi Medical University (General Hospital of Tisco), China;1. Department of Ophthalmology and Vision Rehabilitation, 2nd Chair of Eye Diseases, Medical University of Lodz, Zeromskiego 113, 90-549 ?ód?, Poland;2. Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 ?ód?, Poland;1. Department of Endocrinology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China;2. Department of Endocrinology, Henan University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, Henan, 450003, China;1. Department of Pediatrics, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku 783-8505, Japan;2. Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku 783-8505, Japan;3. Department of Neurosurgery, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku 783-8505, Japan;4. Research Fellow of Japan Society for the Promotion of Science, Japan |
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| Abstract: | BackgroundAssociation between fasting serum glucose (FSG) and certain mineral elements has been extensively reported. Investigation regarding multi-element exposure among subjects with different exposure level is warranted to confirm the association and further explore dose-dependent relationship.MethodsA total of 3488 participants were recruited from four counties of Hunan province, South China. Basic characteristics were collected by face to face interview and 23 elements in plasma were determined by inductively coupled plasma mass spectrometry. We applied fully adjusted generalized linear regression model and multivariable restricted cubic spline function to test the association and dose-response relationship of FSG with 23 elements.ResultsThe results indicated that FSG was positively associated with plasma78selenium level regression coefficient (β), 0.001; 95 % confidence interval (CI), 0.001, 0.001] in a dose-dependent manner, robust to the adjustment for suspected covariates and stratification by age, gender, BMI and smoking status. A negative association was found between FSG and plasma 208lead (β, -0.004; 95 % CI, -0.016, -0.002), 52chromium (β, -0.002; 95 % CI, -0.004, -0.001) and 47titanium (β, -0.001; 95 % CI, -0.002, -0.001).Conclusion78selenium was positively while 208lead, 52chromium and 47titanium were negatively associated with FSG in the present study. However, prospective studies are needed to confirm the results. |
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| Keywords: | Fasting serum glucose Generalized linear regression model |
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