Extensive GTPase crosstalk regulates Golgi trafficking and maturation |
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| Affiliation: | 1. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, 94143, USA;2. George Williams Hooper Foundation, University of California, San Francisco, San Francisco, CA, 94143, USA;1. Division of Neurobiology, Freie Universität Berlin, Germany;2. Graduate School of Biomedical Sciences, UT Southwestern Medical Center, Dallas, USA;1. Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA;2. Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Molecular Biology Research Building, 900 South Ashland Avenue, Chicago, IL 60607, USA;1. Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China;2. Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada;1. Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA;1. State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China;2. School of Life Sciences, Cryo-EM Center, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China |
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| Abstract: | Virtually all transport events at the Golgi complex are regulated by Arf and Rab family GTPases. Recent work has advanced our knowledge regarding the mechanisms controlling GTPase activity, and it has become clear that GTPases do not act in isolation but rather function in complex networks of crosstalk and feedback. Together with earlier findings, these recent studies indicate that communication between GTPases, their regulatory proteins, effectors, and lipids plays a pivotal role in Golgi transport and cisternal maturation. |
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| Keywords: | Golgi Trafficking GTPase Signaling |
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