Selenium levels and skin diseases: systematic review and meta-analysis |
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| Institution: | 1. Department of Dermatology, The Central Hospital of Enshi Autonomous Prefecture, Enshi 445000, China;2. Department of Dermatology, Minda Hospital of Hubei Minzu University, Enshi 445000, China;1. School of Medicine, Universidad Panamericana, Mexico City, Mexico;2. Univerisidad de Papaloapan, Oaxaca, Mexico;3. Laboratory of Developmental Biology Research and Experimental Teratogenicity. Children’s Hospital of Mexico Federico Gomez (HIMFG), Mexico City, Mexico;1. Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, 46202, United States;2. Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, United States;3. School of Health Sciences, Purdue University, West Lafayette, IN, 47907, United States;1. Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India;2. Biotechnology, School of Science, GSFC University, Vadodara, 391750, India;1. Pediatric Research Institute, Departments of Pediatric, University of Louisville School of Medicine, Louisville, KY, USA;2. Center of Cardiovascular Disorders, the First Hospital of Jilin University, Changchun, Jilin, China;3. Departments of Radiation Oncology, Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA;1. Department of Medical Biochemistry, Innlandet Hospital Trust, Lillehammer, Norway;2. Lillehammer Hospital for Rheumatic Diseases, Norway;3. Inland Norway University of Applied Sciences, Elverum, Norway;4. Department of Public Health, Faculty of Nursing sciences, Oslo and Akershus University College, Oslo, Norway;5. University Hospital, Ullevål, Norway;6. Institute of Clinical Sciences, University of Oslo, Norway;7. Department of Medical Biochemistry, Oslo University Hospital, Ullevål, Norway;8. Lab1 AS, Sandvika, Norway;9. Department of Medicine, Innlandet Hospital Trust, Lillehammer, Norway;10. Department of Biology, Faculty of Sciences-l, Lebanese University, Beirut, Lebanon;11. Department of Research, Innlandet Hospital Trust, Brumunddal, Norway;12. Harvard Medical School, Boston, USA;13. Brigham and Women’s Hospital, Boston, USA |
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| Abstract: | BackgroundSeveral studies have investigated the association between selenium levels and skin diseases, but reached inconsistent results.ObjectiveThis systematic review and meta-analysis was conducted to evaluate the association between selenium levels and skin diseases.MethodsA systematic search was conducted in public databases to identify all relevant studies, and study-specific standard mean differences (SMD) and 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups.ResultsTwenty-seven studies were identified with a total of 1315 patient and 7181 healthy controls. Compared with controls, no significant difference in selenium was found in patients with vitiligo (SMD = 0.53, 95% CI: –0.40 to 1.45), alopecia areata (SMD = 0.47, 95% CI: –2.72 and 3.65), or eczema (SMD = 0.12, 95% CI: –0.24 to 0.48). A lower selenium level was found in patients with psoriasis (SMD = –0.62, 95% CI: –1.15 to –0.10), acne vulgaris (SMD = –1.02, 95% CI: –1.45 to –0.60), chloric acne (SMD = –2.35, 95% CI: –3.15 to –1.55), and atopic dermatitis (SMD = –2.62, 95% CI: –3.00 to –2.24). As for disease severity, severe patients had a higher selenium level than mild patients in psoriasis (SMD = 0.72, 95% CI: 0.07–1.38), but no difference was found in vitiligo (SMD = –0.26, 95% CI: –2.38 to 1.85) and alopecia areata (SMD = 0.46, 95% CI: –0.34 to 1.26).ConclusionSelenium levels were associated with several skin diseases and the disease severity, and high selenium levels tended to be a protective factor in certain skin diseases. |
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| Keywords: | Selenium Skin disease Meta-analysis |
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