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Comparison of Target Pocket Similarity and Progress into Research on Inhibitors of Picornavirus 3C Proteases |
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| Authors: | Li Wan Xiaobo Wang Tangle Wang Xiaolan Yuan Wei Liu Yan Huang Changyong Deng Shuang Cao |
| Institution: | 1. Key Laboratory of Green Chemical Engineering Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205 P. R. China
These authors contributed equally to this work.;2. School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, 437100 P. R. China These authors contributed equally to this work.;3. Key Laboratory of Green Chemical Engineering Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205 P. R. China |
| Abstract: | The 3C protease (3C Pro) plays a significant role in the life cycle of picornaviruses from replication to translation, making it an attractive target for structure-based design of drugs against picornaviruses. The structurally related 3C-like protease (3CL Pro) is an important protein involved in the replication of coronaviruses. With the emergence of COVID-19 and consequent intensive research into 3CL Pro, development of 3CL Pro inhibitors has emerged as a popular topic. This article compares the similarities of the target pockets of various 3C and 3CL Pros from numerous pathogenic viruses. This article also reports several types of 3C Pro inhibitors that are currently undergoing extensive studies and introduces various structural modifications of 3C Pro inhibitors to provide a reference for the development of new and more effective inhibitors of 3C Pro and 3CL Pro. |
| Keywords: | 3C protease similarity of target pockets 3C protease inhibitors |