The relationships between serum copper levels and overweight/total obesity and central obesity in children and adolescents aged 6-18 years |
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| Institution: | 1. Department of Family Planning Technical Service, Jining Maternal and Child Health Family Planning Service Center, No.12, Gongxiao Road, Rencheng District, Jining City, Shandong Province, 272000, China;2. Department of Laboratory, Jining Maternal and Child Health Family Planning Service Center, No.12, Gongxiao Road, Rencheng District, Jining City, Shandong Province, 272000, China;1. Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy;2. Department of Biomedical Sciences—Histology, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy;3. Department of Medical Surgical and Experimental Sciences, Ophthalmology Unit, University of Sassari, Viale San Pietro 43/C, 07100 Sassari, Italy;4. I.S.R.C.T.––International Society for Research on Cadmium Toxicity, Viale San Pietro 43/B, 07100 Sassari, Italy;1. Department of Ophthalmology and Vision Rehabilitation, 2nd Chair of Eye Diseases, Medical University of Lodz, Zeromskiego 113, 90-549 ?ód?, Poland;2. Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 ?ód?, Poland;1. L.B.P.O/Section Endocrinology, Faculty of Biological Sciences, USTHB, BP 32 El-Alia, Bab Ezzouar, 16 111 Algiers, Algeria;2. Departement of Biology, Faculty of Biological Sciences and Agricultural Sciences, UMMTO, 15 000 Tizi-Ouzou, Algeria;3. ETH Zurich, Zurich, Switzerland;4. Iodine Global Network, Ottawa, Ontario, Canada;5. Endocrinology Department, Public Hospital Etablishment IbnZiri, Bologhine, 16090 Algiers, Algeria;1. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Research and Development, Sodour Ahrar Shargh Company, Tehran, Iran;3. Department of Pathology, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Department of Pharmaceutics and Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Urology and Nephrology Research Center, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Laboratory of Microscopy Applied to Reproduction, Department of Histology, Embryology and Cell Biology, Institute of Biological Sciences, Federal University of Goiás, Goiania, Goias 74001970, Brazil;2. Laboratory of Microscopy and Microanalysis, Department of Biology, University Estadual Paulista – UNESP, Rua Cristóvão Colombo, 2265, São José do Rio Preto, Sao Paulo 15054000, Brazil;3. Laboratory of Molecular and Biochemistry Pharmacology, Department of Pharmacology, Institute of Biological Sciences, Federal University of Goiás, Goiania Goias 74001970, Brazil |
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| Abstract: | ObjectiveTo explore the relationships between serum copper levels and overweight/total obesity and central obesity in children and adolescents.MethodsWe included 2,000 children and adolescents from the 2011-2016 US National Health and Nutrition Examination Surveys. The multivariable linear model, logistic model and restricted cubic splines were adopted to assess the relationships. Models were adjusted for data release cycle, age, sex, race/ethnicity, ratio of family income to poverty, and dietary intakes of protein, total sugars, total fat, fiber, energy, calcium, vitamin D, vitamin C, and hours watch television or videos.ResultsThe prevalences of overweight/total obesity and central obesity were 37.38% and 33.40%, respectively. For per-quintile increment in serum copper levels, body mass index increased by 1.06 (0.79-1.33) (kg/m2) and waist circumference increased by 2.43 (1.58-3.27) (cm). The odds ratios (95% confidence intervals) for overweight/total obesity and central obesity among participants with the highest quintile compared with those with the lowest quintile of serum copper levels were 5.46 (3.31-8.98) and 5.64 (3.31-9.58), respectively. The above-mentioned associations were not modified by age (children: 6-12 years, adolescents: 13-18 years) and sex. Dose-response analysis showed that the odds of overweight/total obesity and central obesity increased with increasing serum copper levels to a level of approximate 140 ug/dL where the association seemed to reach a plateau, respectively.ConclusionsSerum copper levels were positively associated with body mass index and waist circumference, and elevated serum copper levels were associated with higher odds of overweight/total obesity and central obesity in children and adolescents. |
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| Keywords: | Serum copper Overweight Obesity Children and adolescents National Health Nutrition Examination Survey |
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