Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms |
| |
| Affiliation: | 1. Department of Pharmacology and Toxicology, School of Pharmacy, Medicinal plant and natural products Research Center, Hamadan University of Medical Sciences, Hamadan 6517838678, Iran;2. Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran;1. Centro Tecnológico de la Carne de Galicia, Ourense, Spain;2. Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia;3. Andrija Štampar Teaching Institute of Public Health, Zagreb, Croatia;4. Department of Food Engineering, Faculty of Animal Science and Food Engineering, University of São Paulo, São Paulo, Brazil;5. Department of Fruit and Vegetable Product Technology, Wacław Dąbrowski Institute of Agricultural and Food Biotechnology, Warsaw, Poland;6. Burn and Wound Healing Research Center, Division of Food and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran;7. Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Faculty of Pharmacy, Universitat de València, València, Spain;1. Department of Pharmacology, Sinhgad Institute of Pharmaceutical Sciences, Lonavala 410401, Maharashtra, India;2. Department of Pharmacology, Sinhgad Institute of Pharmacy, Nerhe, Pune, Maharashtra, India;3. Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad 382 481, Gujarat, India |
| |
| Abstract: | BackgroundNeurodegenerative diseases (NDDs) are primarily characterized by selective neuronal loss in the brain. Alzheimer's disease as the most common NDDs and the most prevalent cause of dementia is characterized by Amyloid-beta deposition, which leads to cognitive and memory impairment. Parkinson's disease is a progressive neurodegenerative disease characterized by the dramatic death of dopaminergic neuronal cells, especially in the SNc and caused alpha-synuclein accumulation in the neurons. Silymarin, an extract from seeds of Silybum marianum, administered mostly for liver disorders and also had anti-oxidant and anti-carcinogenic activities.PurposeThe present comprehensive review summarizes the beneficial effects of Silymarin in-vivo and in-vitro and even in animal models for these NDDs.MethodsA diagram model for systematic review is utilized for this search. The research is conducted in the following databases: PubMed, Web of Science, Scopus, and Science Direct. Results: Based on the inclusion criteria, 83 studies were selected and discussed in this review.ConclusionLastly, we review the latest experimental evidences supporting the potential effects of Silymarin, as a neuroprotective agent in NDDs. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
