New insights into the regulation of apoptosis,necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8 |
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| Affiliation: | 1. Institute for Genetics & Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany;2. Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany;1. The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia;2. Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia;1. The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, Fulham Road, London, SW3 6JB, UK;1. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;2. Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;3. Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA;1. Master of Science in Biomedical Sciences Program, Tufts University School of Medicine, Boston, MA 02111, USA;2. Medical Scientist Training Program and Program in Neuroscience, Sackler Graduate School, Tufts University, Boston, MA 02111, USA;3. Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA;1. Program in Cell Death and Survival Networks, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA;2. Department of Molecular Biology and Biochemistry, Institute for Immunology, University of California, Irvine, CA 92697, USA;1. Program in Pharmacology and Experimental Therapeutics, Sackler Graduate School, Tufts University, Boston, MA 02111, USA;2. Medical Scientist Training Program and Program in Neuroscience, Sackler Graduate School, Tufts University, Boston, MA 02111, USA;3. Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA;4. Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA;5. Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA;6. Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA 02111, USA;7. Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA;8. Institute for Genetics, Center for Molecular Medicine and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50674 Cologne, Germany;9. Neuroscience Center and Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA |
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| Abstract: | Necroptosis and pyroptosis are inflammatory forms of regulated necrotic cell death as opposed to apoptosis that is generally considered immunologically silent. Recent studies revealed unexpected links in the pathways regulating and executing cell death in response to activation of signaling cascades inducing apoptosis, necroptosis, and pyroptosis. Emerging evidence suggests that receptor interacting protein kinase 1 and caspase-8 control the cross-talk between apoptosis, necroptosis, and pyroptosis and determine the type of cell death induced in response to activation of cell death signaling. |
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| Keywords: | Cell death Inflammation Apoptosis Necroptosis Pyroptosis RIPK1 Caspase-8 |
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