Phytochemicals targeting matrix metalloproteinases regulating tissue degradation in inflammation and rheumatoid arthritis |
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| Institution: | 1. Laboratory of Cardiovascular Research and Integrative Pharmacology, College of Pharmacy University of Sargodha, Sargodha, Pakistan;2. University College of Pharmacy, University of Punjab Lahore, Lahore, Pakistan;3. Department of Basic medical science, Faculty of Pharmacy, Gomal University, DI Khan, KPK, Pakistan;1. Faculty of Chinese Medicine/State Key Laboratory of Quality Research in Chinese Medicine/Institute of Rheumatic Diseases, Macau University of Science and Technology, Avenida Wailong, Taipa, Macau, PR China;2. Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People''s Republic of China, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, PR China;1. Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea;2. Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA;3. Department of Thoracic and Cardiovascular Surgery, CHA Gumi Medical Center, CHA University, Gumi 730-040, Republic of Korea;4. Bio-Materials Research Institute, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 580-185, Republic of Korea;5. Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea;6. College of Pharmacy, Yeungnam University, Gyeongbuk 712-749, Republic of Korea;7. College of Pharmacy, Woosuk University, Jeonju 565-701, Republic of Korea;8. Department of Immunology, School of Medicine, Keimyung University, Daegu 704-701, Republic of Korea |
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| Abstract: | PurposeMatrix metalloproteinases, zinc dependent proteolytic enzymes, have significant implications in extracellular matrix degradation associated with tissue damage in inflammation and Rheumatoid arthritis. Numerous orchestrated pathways affects instigation and blockade of metalloproteinases as well as various factors that increase the expression of MMPs including inflammatory cytokines, hormones and growth factors. Direct inhibition of these proteolytic enzymes or modulation of these pathways can provide protection against tissue destruction in inflammation and rheumatoid arthritis. Inclination towards use of plant derived phytochemicals to prevent tissue damage has been increasing day by day. Diversity of phytochemicals have been known to directly inhibit metalloproteinases. Hence, thorough knowledge of phytochemicals is very important in novel drug discovery.MethodsPresent communication evaluates various classes of phytochemicals, in effort to unveil the lead molecules as potential therapeutic agents, for prevention of MMPs mediated tissue damage in inflammation and rheumatoid arthritis. Data have been analyzed through different search engines.ResultsNumerous phytochemicals have been studied for their role as MMPs inhibitors which can be processed further to develop into useful drugs for the treatment of inflammation and rheumatoid arthritis.ConclusionIn search of new drugs, phytochemicals like flavonoids, glycosides, alkaloids, lignans & terpenes offer a wide canvas to develop into valuable forthcoming medicaments. |
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