Diagnostic potential of ionomic profile in the plasma of cervical cancer patients receiving neoadjuvant chemoradiotherapy |
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| Affiliation: | 1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China;2. Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha, 410078, PR China;3. Department of Clinical Laboratory Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China;4. Department of General Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China;5. Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, 410078, PR China;6. National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008, Hunan, PR China;7. College of Chemistry & Chemical Engineering, Central South University, Changsha, 410083, PR China;8. Department of Oncology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, PR China;1. Division of Rheumatology, Department of Internal Medicine, University of Michigan, North Campus Research Complex, B014 G236, 2800 Plymouth Road, SPC 2800, Ann Arbor, MI 48109-2800, USA;2. Department of Obstetrics and Gynecology, University of Michigan, North Campus Research Complex, B014 G236, 2800 Plymouth Road, SPC 2800, Ann Arbor, MI 48109-2800, USA;3. Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA;1. NanoScience Technology Center, Department of Chemistry, Department of Materials Science and Engineering, and CREOL, The College of Optics and Photonics, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, FL 32826, USA;2. Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, FL 32827, USA;1. Department of Obstetrics and Gynecology, Soroka University Medical Center, Rager Boulevard, PO Box 151, Beer Sheva 85025, Israel;2. Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel;1. Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China;2. Institute of Radiation Medicine, Fudan University, Shanghai, China;3. Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, United States;4. Research Center, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China;1. Department of Advanced Operative and Oncologic Gynecology, Asklepios Hospital, Hamburg, Germany;2. Department of Gynecologic Oncology, Erasto Gaertner Hospital, Curitiba, Brazil;3. Department of Radiooncology, University of Cologne, Cologne, Germany;4. Institute for Cytology and Dysplasia, Fürstenberg-Carree, Berlin, Germany;5. Department of Gynecology, Park Clinic, Kiel, Germany |
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| Abstract: | Background and aimMajor and trace elements play an important role in human body, and it has been reported that ionomic distribution differ greatly in tumor patients. The aim of the present study was to investigate the effects of cisplatin-based neoadjuvant chemoradiotherapy on the ionomic profile in human plasma as a potential biomarker for the therapeutic effects of cervical cancer.MethodThirty-seven patients with cervical cancer receiving neoadjuvant chemoradiotherapy were included in this study, pretherapy and post-treatment blood samples were collected and concentrations of 24 ions were analyzed by inductively coupled plasma mass spectrometry (ICP-MS).ResultsThe results showed that after cisplatin chemotherapy and radiotherapy, patients' plasma Pt level significantly increased, Na, Mg, P, K, Ca, Se, Cu, Zn, Se, Sr, Ba levels significantly decreased (P < 0.01), and Al, Cu ions were significantly correlated with the treatment effect (P < 0.05). In addition, the pattern of elemental correlations changed dramatically after the neoadjuvant chemoradiotherapy.ConclusionThe results indicated that the plasma ionomic profile may serve as a quick and convenient tool to reflect the therapeutic effect of cisplatin-based chemoradiotherapy in cervical cancer patients, and supplement of certain essential elements may be of great importance for the maintenance of ion homeostasis in human body and for the reduction of adverse effect of chemotherapy and radiotherapy. |
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| Keywords: | Ionomics Cervical cancer Neoadjuvant chemoradiotherapy ICP-MS Diagnosis |
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