Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology |
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| Affiliation: | 1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children''s Hospital, Boston, MA 02115, USA;2. School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China;1. UNC Department of Cell Biology and Physiology, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA;2. UNC Neuroscience Center, 115 Mason Farm Road, Chapel Hill, NC, 27599, USA;3. UNC Lineberger Comprehensive Cancer Center, 101 Manning Dr, Chapel Hill, NC, 27514, USA;1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;2. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA;3. MTA-DE Momentum, Laboratory of Protein Dynamics, Department of Biochemistry and Molecular Biology, University of Debrecen, 4010 Debrecen, Hungary;1. Department of Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA;2. Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA;3. Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA |
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| Abstract: | Higher-order supramolecular complexes–dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein–protein interactions or by dynamic liquid–liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights. |
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