Relationship between occupational aluminium exposure and histone lysine modification through methylation |
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| Affiliation: | 1. Department of Occupational Health, School of Public Health, Shanxi Medical University, China;2. Key Lab of Environmental Hazard and Health of Shanxi Province, Shanxi Medical University, China;3. Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, China;4. Sixth Hospital of Shanxi Medical University (General Hospital of Tisco), China;1. Department of Ophthalmology and Vision Rehabilitation, 2nd Chair of Eye Diseases, Medical University of Lodz, Zeromskiego 113, 90-549 Łódź, Poland;2. Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland;1. Laboratory of Microscopy Applied to Reproduction, Department of Histology, Embryology and Cell Biology, Institute of Biological Sciences, Federal University of Goiás, Goiania, Goias 74001970, Brazil;2. Laboratory of Microscopy and Microanalysis, Department of Biology, University Estadual Paulista – UNESP, Rua Cristóvão Colombo, 2265, São José do Rio Preto, Sao Paulo 15054000, Brazil;3. Laboratory of Molecular and Biochemistry Pharmacology, Department of Pharmacology, Institute of Biological Sciences, Federal University of Goiás, Goiania Goias 74001970, Brazil;1. Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, 410078, China;2. Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, 410013, China;3. Environmental Science and Engineering, College of Resource and Environment, Hunan Agricultural University, Changsha, 410128, China;4. Department of Occupational and Environmental Health, Huazhong University of Science and Technology, Wuhan, 430030, China;5. Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, 410078, China;6. Hunan Occupational Disease Prevention and Control Institute, Changsha, 410007, China;7. Public Health College, Kunming Medical University, Kunming, 650500, China;8. Center for Environment and Health in Water Source Area of South-to-North Water Diversion, Hubei University of Medicine, Shiyan, 442000, China;9. Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China;2. SINTEF Materials and Chemistry, Sem Sælands vei 12, Trondheim, NO-7465, Norway;3. PRIME Laboratory, Purdue University, 525 Northwestern Avenue, West Lafayette, Indiana, 47907-2036, USA;1. Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, China;2. Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Province Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Changsha 410125, Hunan, China;3. Henan Guang’an Biology Technology Co. Ltd., Zhengzhou 450001, China;4. Yunan Yin Yulong Academician Workstation, Yunan Xinan Tianyou Animal Huabandry Technology Co., Ltd., Shalang Town, Wuhua District, Kunming 6500323, Yunnan Province, China;1. Professor of Medicine and Epidemiology & Community Medicine, University of Ottawa Senior Scientist, Ottawa Hospital Research Institute Scientist, Institute for Clinical Evaluative Sciences, Ottawa, Canada;2. Department of Medicine, University of Ottawa, Ottawa, Canada;3. Department of Pathology & Lab. Medicine, University of Ottawa Clinical Biochemist - Division of Biochemistry, The Ottawa Hospital, Ottawa, Canada |
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| Abstract: | BackgroundAluminium is an environmental neurotoxin to which human beings are extensively exposed. However, the molecular mechanism of aluminium toxicity remains unclear.MethodsThe changes in cognitive function of aluminum exposed workers under long-term occupational exposure were evaluated, and the relationship between cognitive changes, plasma memory related BDNF and EGR1 protein expression, and variations of epigenetic markers H3K4me3, H3K9me2, H3K27me3 expression levels in blood was explored.ResultsMMSE, DSFT, DST scores in cognitive function and the levels of plasma BDNF and EGR1 protein expression decreased with the increase of blood aluminum level. H3K4me3, H3K9me2, H3K27me3 expression levels in peripheral blood lymphocytes of aluminum exposed workers were statistically different (all P<0.05). H3K4me3, H3K9me2 and H3K27me3 expression levels in lymphocytes were correlated with blood aluminum level. BDNF, EGR1 protein level and H3K4me3, H3K9me2, H3K27me3 expression levels have different degrees of correlation. There was a linear regression relationship between plasma BDNF, H3K4me3 and H3K9me2. H3K9me2 had a greater effect on BDNF than H3K4me3. There is a linear regression relationship between EGR1, H3K4me3 and H3K27me3, and the influence of H3K4me3 on EGR1 is greater than that of H3K27me3 on EGR1.ConclusionAlummnum may regulate the expression of BDNF and EGR1 by regulating H3K4me3, H3K27me3 and H3K9me2, and affect the cognitive function of workers by affecting the expression of BDNF and EGR1. |
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| Keywords: | Aluminium Cognitive function Histone lysine methylation Brain-derived neurotrophic factor (BDNF) Early growth response protein 1(EGR1) |
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