Origin,production and molecular determinants of macrophages for their therapeutic targeting |
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Authors: | Sangita Chowdhury Arun K. Trivedi |
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Affiliation: | 1. LSS008 Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, India Contribution: Investigation, Resources, Validation, Writing - original draft;2. LSS008 Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, India |
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Abstract: | Macrophages, the most heterogeneous cells of the hematopoietic system and the giant eaters of the immune system that present either as tissue-resident cells or infiltrated immune cells, eliminate foreign pathogens and microbes and also play different physiological roles to maintain the body's immune response. In this review, we basically provide a broad overview of macrophages from their origin, functional diversity to M1-M2 polarization, specialized markers, and their role as important therapeutic targets in different diseases based on the current research and evidence. Apart from this, we have precisely discussed about tumor-associated macrophages (TAMs) and their role in tumor progression and newly discovered lesser-known markers of TAMs that could be used as potential therapeutic targets to treat life-threatening diseases. It is really very important to understand the diversity of macrophages to develop TAM-modulating strategies to activate our own immune system against diseases and to overcome immune resistance. |
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Keywords: | immune cells macrophages polarization tumor-associated macrophages tumor progression |
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