Effects of high potassium iodate intake on iodine metabolism and antioxidant capacity in rats |
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| Institution: | 1. Key Laboratory of Trace Element Nutrition of National Health Commission of China, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Beijing 100050, China;2. Animal Laboratory, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100050, China;1. Clinical Medical College, Dali University, Dali, Yunnan, China;2. Affiliated Hospital of Guizhou Medical University, Guiyang, China;3. Department of Oncology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China;4. Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China;1. School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, China;2. Guizhou Orthopedics Hospital, Guiyang, 550007, China;1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan;2. Surface and Nano Analysis Research Group, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 5, 1-1-1 Higashi Tsukuba, Ibaraki 305-8565, Japan;3. Department of Applied Chemistry, School of Engineering, Tokyo Denki University, 5 Senju-Asahi-cho, Adachi, Tokyo 120-8551, Japan;1. Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, Poland;2. Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, 35 Wolynska Street, 60-637 Poznan, Poland;1. Vila Velha University – UVV, Laboratory of Applied Ichthyology (LAB PEIXE), Comissário José Dantas de Melo, 21, Boa Vista, 29102-770, Vila Velha, ES, Brazil;2. Federal University of Espírito Santo - UFES, Department of Chemistry, Fernando Ferrari, 514, Goiabeiras, 29075-910, Vitória, ES, Brazil;1. Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey;2. Department of Child and Adolescent Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey;3. Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Selçuk University, Konya, Turkey |
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| Abstract: | BackgroundKIO3 and KI are the most common salt iodization agents. Coincidentally, iodine exists naturally in high-iodine drinking water in the form of iodide (I?) or iodate (IO3?). As an oxidizing substance, IO3? should be reduced to I? before it can be effectively used by the thyroid. However, there is a lack of systematic studies on the metabolic process of high dose KIO3 in vivo.MethodsThe iodine metabolism processes in the thyroid and serum of rats after high KIO3 intake were determined using high-performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC/ICP–MS) and arsenic cerium catalytic spectrophotometry. The changes of redox activity in the serum, thyroid, liver, and kidneys were observed by detecting total antioxidative activity (TAA).ResultsHigh doses of IO3? were completely reduced to I? in vivo within 0.5 h. The level of organic bound iodine in the serum was stable, while the organic bound iodine in the thyroid increased to a plateau after intake of high-dose KIO3. The levels of total iodine and I? in serum and thyroid increased quickly, then all decreased after reaching the maximum absorption peak, and I? had two absorption peaks in serum. The thyroid blocking dose of I? was 0.5 mg/kg in rat. Additionally, high KIO3 intake did not influence the TAA in serum and other tissues.ConclusionThe body is able to reduce and utilize high doses of KIO3 ingested through the digestive tract. The metabolism of high KIO3 in vivo is characterized by two absorption process of I? in serum and the thyroid blocking effect. Moreover, a single intake of high-dose KIO3 does not affect TAA in vivo. The results suggest that such excess IO3? may have be reduced in the digestive tract before I? enters the blood. |
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| Keywords: | Potassium iodate Iodine metabolism Antioxidant capacity Rat |
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