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Tiny Drosophila intestinal stem cells,big power |
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| Authors: | Jingbo Zhai Wanyang Li Xin Liu Di Wang Dongli Zhang Yanli Liu Xiuwen Liang Zeliang Chen |
| Affiliation: | 1. Medical College, Inner Mongolia Minzu University, Tongliao, China;2. Medical College, Inner Mongolia Minzu University, Tongliao, China Contribution: Funding acquisition, Investigation;3. Medical College, Inner Mongolia Minzu University, Tongliao, China Key Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region, Tongliao, China Brucellosis Prevention and Treatment Engineering Research Center of Inner Mongolia Autonomous Region, Tongliao, China Contribution: Data curation, Funding acquisition;4. Medical College, Inner Mongolia Minzu University, Tongliao, China Key Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region, Tongliao, China Brucellosis Prevention and Treatment Engineering Research Center of Inner Mongolia Autonomous Region, Tongliao, China Contribution: Funding acquisition, Writing - original draft;5. Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, China Contribution: Formal analysis, Funding acquisition;6. Hulunbuir City People's Hospital, Hulunbuir City, China |
| Abstract: | The signaling pathways are highly conserved between Drosophila and mammals concerning intestinal development, regeneration, and disease. The powerful genetic tools of Drosophila make it a valuable and convenient alternative to answer basic biological questions that can not be addressed using mammalian models. In this review, we discuss recent advances in how we use fly midgut to answer the following key questions: (1) How intestine stem cell niches are established; (2) which factors control asymmetric division of stem cells; (3) how intestinal cells interact with environmental factors, such as tissue damage, microbiota, and diet; (4) how to screen aging/cancer-related factors or drugs by fly intestine stem cells. |
| Keywords: | Drosophila microbiota midgut signaling crosstalk stem cells |