Antifungal Activity,Antibiofilm and Association Studies with O-Alkylamidoximes against Cryptococcus spp. |
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| Authors: | Anna Paula de Castro Teixeira Gustavo Fernandes Queiroga Moraes Romário Jonas de Oliveira Cosme Silva Santos Rodrigo Ribeiro Alves Caiana Juliano Carlo Rufino de Freitas Ulrich Vasconcelos Fillipe de Oliveira Pereira Igara Oliveira Lima |
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| Institution: | 1. Postgraduate Program in Natural Sciences and Biotechnology, Education and Health Center, Federal University of Campina Grande, Cuité, Brazil;2. Biochemistry Laboratory, Education and Health Center, Federal University of Campina Grande, Cuité, Brazil;3. Postgraduate Program in Chemistry, Federal Rural University of Pernambuco, Recife, Brazil;4. Laboratory of Animal Microbiology, Biotechnology Center, Federal University of Paraíba, João Pessoa, Brazil |
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| Abstract: | This is the first study that describes the antifungal and anti-biofilm potential of O-alkylamidoximes against strains of Cryptococcus neoformans and Cryptococcus gattii. In vitro tests have shown that O-alkylamidoximes are capable of inhibiting fungal growth and biofilm formation of the C. neoformans and C. gattii strains, suggesting, from molecular docking, the potential for interaction with the Hsp90. The associations between O-alkylamidoximes and amphotericin B were beneficial. Therefore, O-alkylamidoximes can be a useful alternative to contribute to the limited arsenal of drugs, since they showed a powerful action against the primary agents of Cryptococcosis. |
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| Keywords: | O-alkylation reaction O-alkylamidoximes antifungals cryptococcal meningitis combination |
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