Highly Oxygenated Labdane Diterpenoids from Stevia rebaudiana and Their Anti-Atherosclerosis Activities |
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Authors: | Bin Cheng Fei Fang Qin-Tao Zhou Yan Li Xue-Wen Wu Xue-Rong Zhao De-Wen Bi Xing-Jie Zhang Rui-Han Zhang Xu Ji Xiao-Li Li Guang Cao Wei-Lie Xiao |
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Affiliation: | Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650500 P. R. China |
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Abstract: | Five unknown labdane diterpenoids Stevelins A–E ( 1–5 ), three known labdane diterpenoids ( 6–8 ) and three labdane norditerpenoids ( 9–11 ) were isolated from the Stevia rebaudiana. The structures were determined primarily via NMR spectroscopic data and HR-ESI-MS experiments. X-ray crystallography using CuKα radiation was used to determine the absolute configurations of 1 , and the absolute configurations of 2–5 were deduced by electronic circular dichroism (ECD) calculations. The potential anti-atherosclerosis activities of all compounds were evaluated by measuring their inhibitory effects on the macrophage foam cell formation. As a result, most isolated compounds could significantly inhibit oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation, which suggests that these compounds may be promising candidates in the treatment for atherosclerosis. |
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Keywords: | Stevia rebaudiana labdane diterpenoids anti-atherosclerosis activity |
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