Fat/Dachsous family cadherins in cell and tissue organisation |
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| Affiliation: | 1. Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA;2. Lunenfeld-Tanenbaum Research Institute, Sinai Health Systems, Toronto, Canada;3. Department of Molecular Genetics, University of Toronto, Toronto, Canada;1. Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA;2. Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada;3. Department of Medical Biophysics, University of Toronto, Toronto, Canada;4. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA;5. Department of Molecular Genetics, University of Toronto, Toronto, Canada;6. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada;1. Research Center for Biosignal, Akita University, Akita 010-8543, Japan;2. Department of Cell Biology and Morphology, Akita University Graduate School of Medicine, Akita 010-8543, Japan;3. Global COE program, Gunma University and Akita University, Akita 010-8543, Japan;4. Research Institute for Electronic Science, Hokkaido University, Hokkaido 060-0812, Japan;5. Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna 1030, Austria;6. Department of Medical Biology, Akita University Graduate School of Medicine, Akita 010-8543, Japan;7. Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan;1. Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA |
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| Abstract: | Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell polarity. Here we describe the recent advances in understanding how these large cadherins coordinate these processes, and discuss additional progress extending their function in regulation of microtubules, migration and disease. |
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| Keywords: | Fat Dachsous Planar cell polarity Hippo signalling |
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