Exposure to lead increases the risk of meningioma and brain cancer: A meta-analysis |
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| Affiliation: | 1. School of Medicine, College of Arts & Science of Jianghan University, Wuhan 430000, China;2. School of Health Sciences, Wuhan University, Wuhan 430071, China;3. School of Geodesy and Geomatics, Wuhan University, Wuhan 430079, China;1. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN;2. Department of Health Sciences Research, Mayo Clinic, Rochester, MN;3. Department of Radiation Oncology, Mayo Clinic, Rochester, MN;4. Department of Neurology, Mayo Clinic, Rochester, MN;5. Department of Radiology, Mayo Clinic, Rochester, MN;1. Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China;2. Clinical Skill Training Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China;1. Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, 450016, China;2. Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, 450001, China |
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| Abstract: | ObjectiveTo analyze the relationship between environmental lead exposure and various types of brain tumors.MethodsSearch databases PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure (CNKI) as of July 1, 2019. Stata 15.0 software was used for analysis.ResultsIn the case control, lead exposure was associated with gliomas and meningiomas 0.82 (95 % CI: 0.69, 0.95) and 1.06 (95 % CI: 0.65, 1.46). In the cohort study, lead exposure was associated with brain cancer and meningiomas 1.07 (95 % CI: 0.95, 1.19) and 1.06 (95 % CI: 0.94, 1.17). The risk of childhood brain tumors associated with parental lead exposure was 1.17 (95 % CI: 0.99, 1.34).ConclusionsLead may be a risk factor for meningiomas and brain cancers. However, the glioma results suggest that lead may be a protective factor, which needs to be further studied. |
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| Keywords: | Lead exposure Brain tumor Meta-analysis |
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