Three New Cembranoids from a Xisha Soft Coral Sarcophyton sp. |
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| Authors: | Xue Leng Jing Liu Xiao Han Te Li Han Ouyang Xia Yan Shan He |
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| Institution: | 1. Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800 Zhejiang, China;2. Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211 Zhejiang, China |
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| Abstract: | Chemical investigation of the Xisha soft coral Sarcophyton sp. has led to the isolation of eight cembrane-type diterpenoids, including three new compounds, namely sarcophynoids A-C ( 1 – 3 ), and five known analog compounds ( 4 – 8 ). Their structures were clarified based on spectroscopic analysis, and computer-assisted methods including TDDFT-ECD calculation and the quantum mechanical-nuclear magnetic resonance (QM-NMR) method. All the above compounds were tested for their antibacterial activities. Among them, compounds 4 – 7 and 8 exhibited antibacterial activities against S. aureus, B. subtilis, and P. aeruginosa, with MIC of 4–64 μg/mL. |
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| Keywords: | soft coral Sarcophyton sp cembranoid diterpenes antibacterial activity |
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