SeO2 induces apoptosis with down-regulation of Bcl-2 and up-regulation of P53 expression in both immortal human hepatic cell line and hepatoma cell line |
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Authors: | Yaming Wei Xiaozhe Cao Yinxian Ou Jihong Lu Chuanping Xing Rongliang Zheng |
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Abstract: | An immortal human hepatic cell line HL-7702 and human hepatoma cell line SMMC-7721 were treated with 3–30 μM SeO2. SeO2 at 30 μM markedly inhibited cell proliferation and viability, and prompted apoptosis of both normal hepatic and hepatoma cells after 48 h treatment. SeO2 could also down-regulate the Bcl-2 level, greatly in HL-7702 and slightly in SMMC-7721 cells, but up-regulate wild type P53 level a little in HL-7702 and significantly in SMMC-7721 cells. The Bcl-2/P53 value was closely correlated with the apoptotic rate as well as SeO2 concentrations. |
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Keywords: | Selenium Apoptosis Bcl-2 protein P53 protein HL-7702 SMMC-7721 |
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