Synthesis of 1-(omega-aminoalkyl)naphthoindolediones with antiproliferative properties |
| |
| Authors: | Shchekotikhin Andrey E Buyanov Vladimir N Preobrazhenskaya Maria N |
| |
| Institution: | Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, B. Pirogovskaya, 11, Moscow 119021, Russia. mnp@space.ru |
| |
| Abstract: | The preparation and cytotoxic properties of 4,11-dihydroxynaphtho2,3-f]indole-5,10-dione derivatives carrying N-aminoalkyl substituents are described. The N-aminobutylnaphthoindolediones obtained were studied in National Cancer Institute Screening Program and demonstrated high antiproliferative activity against 60 human cancer cell lines. All N-(4-aminobutyl) derivatives have higher potency than adriamycin or mitoxantrone against adriamycin selected multidrug resistant breast cancer cell line NCI/ADR. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
