Observations on the permeability of the choriocapillaris of the eye |
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Authors: | Dr. Edward Essner Sheldon R. Gordon |
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Affiliation: | (1) Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan, USA;(2) Kresge Eye Institute, 3994 John R., 48201 Detroit, MI, USA |
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Abstract: | Summary The choriocapillaris is a fenestrated capillary bed located posterior to the retinal pigment epithelium. It serves as the main source of supply to the photoreceptors, retinal pigment epithelium, and other cells of the outer retina. The permeability of these capillaries to intravenously injected ferritin (MW — approx. 480,000; mol. diam. 11 nm) was examined in the mouse, rabbit, and guinea pig, each of which is characterized by a different type of retinal vascularization. In all three species, the bulk of the ferritin remained in the capillary lumina, where it appeared to be blocked at the level of the diaphragmed fenestrae. Some ferritin was present in endothelial cell vacuoles. The results confirm previous work on the rat choriocapillaris and indicate that the barrier function of the choriocapillary endothelium is present even among species in which the retinal circulation differs significantly.Supported by NIH grant EY03418 |
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Keywords: | Capillary Endothelium Ferritin Permeability |
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