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Computational modeling and prediction of deletion mutants
Affiliation:1. Center of Structural Biology, Vanderbilt University, Nashville, TN 37235, USA;2. Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37235, USA;3. Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA;4. Institute for Drug Discovery, Leipzig University Medical School, 04103 Leipzig, Germany;1. Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA;2. Centro de Investigaciones Biológicas Margarita Salas (CIB), CSIC, 28040 Madrid, Spain;3. Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA;1. Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC, Australia;2. ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC, Australia;1. National Research Nuclear University MEPhI, Kashirskoye shosse 31, Moscow 115409, Russia;2. JSC Aquaservice, Kashirskoe shosse 31, Moscow 115409, Russia;1. Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA;2. Molecular Microbiology and Structural Biochemistry (MMSB, UMR 5086), CNRS & University of Lyon, 7 Passage du Vercors, 69007 Lyon, France;1. D. E. Shaw Research, New York, NY 10036, USA;2. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA;1. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA;2. QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, San Francisco, CA 94158, USA;3. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA;4. Chan Zuckerberg Biohub, San Francisco, CA 94158, USA;5. QBI, University of California, San Francisco, San Francisco, CA 94158, USA;6. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA;7. The University of California, Berkeley–University of California, San Francisco Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA 94158, USA;8. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA;9. Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA;10. Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Abstract:
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  • Keywords:Deletion  mutation  AlphaFold  Modeling  SAM domain  indel  Rosetta  ΔΔG  NMR
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