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Structural insights into the regulation of peptidoglycan DL-endopeptidases by inhibitory protein IseA
Institution:1. College of Pharmacy, Yeungnam University, Gyeongsan 38541, South Korea;1. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China;1. Center of Structural Biology, Vanderbilt University, Nashville, TN 37235, USA;2. Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37235, USA;3. Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA;4. Institute for Drug Discovery, Leipzig University Medical School, 04103 Leipzig, Germany;1. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS), Beijing 100101, P.R. China;2. University of Chinese Academy of Sciences, Beijing 100049, P.R. China;1. Protein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA;2. Cancer Innovation Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA;1. Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China;2. Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia;3. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China;1. T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA;2. Biomolecular NMR Center, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA
Abstract:
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  • Keywords:crystal structure  peptidoglycan DL-endopeptidase  DL-endopeptidase inhibition  bactericidal activity
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