Hexanucleotide Repeat Expansion in C9ORF72 Is Not Detected in the Treatment-Resistant Schizophrenia Patients of Chinese Han |
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| Authors: | Xijia Xu Shiping Xie Xiaomeng Shi Jie Lv Xiaowei Tang Xiaolan Wang Shuiping Lu Mingzhong Wang Xiaobing Zhang Jing Sun Hui Yao |
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| Institution: | 1. Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.; 2. Nanjing Brain Hospital, Nanjing University Medical School, Nanjing, 210093, China.; 3. Department of Psychiatry, Nanjing Qinglongshan Mental Hospital, Nanjing, 211123, China.; 4. Department of Psychiatry, Affiliated Wutaishan Hospital of Medical College of Yangzhou University, Yangzhou, 225003, China.; the Second Xiangya Hospital of Central South University, CHINA, |
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| Abstract: | Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia–amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis. HRE was also seen in the genomes of patients suffering from several other degenerative diseases. However, whether it is present in the treatment-resistant schizophrenia patients remains unknown. Genotyping 386 patients suffering from treatment-resistant schizophrenia using the method of Repeat-Primed PCR, we reported here that no HRE was detected in the patients of Chinese Han. |
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