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Restoring the youthful state of striatal plasticity in aged mice re-enables cognitive control of action
Affiliation:1. Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia;1. Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA;1. University of Kentucky, Lexington, KY, USA;1. Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada;2. Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada;3. Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON M5S 1A8, Canada;4. Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada;1. Animal Physiology Unit, Institute of Neurobiology, University of Tübingen, 72076 Tübingen, Germany;1. Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, 3012 Bern, Switzerland;2. Interfaculty Bioinformatics Unit, University of Bern, Baltzerstrasse 6, 3012 Bern, Switzerland;3. Swiss Institute of Bioinformatics, Amphipôle, Quartier UNIL-Sorge, 1015 Lausanne, Switzerland;1. Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, 130 McAllister Way, Santa Cruz, CA 95060, USA;2. Department of Paleobiology, National Museum of Natural History, Smithsonian Institution, 10th Street NW and Constitution Avenue NW, Washington, DC 20560, USA;3. Institute of Marine Sciences, University of California, Santa Cruz, 130 McAllister Way, Santa Cruz, CA 95064, USA;4. Department of Paleontology and Geology, Burke Museum of Natural History and Culture, 4303 Memorial Way Northeast, Seattle, WA 98105, USA;5. Department of Earth and Planetary Sciences, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA
Abstract:
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  • Keywords:striatum  direct pathway  indirect pathway  spiny projection neurons  D1-SPNs  D2-SPNs  goal-directed  habits  intracellular signaling  aging  action-outcome contingency  instrumental learning  outcome devaluation
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