Co-localization of nitric oxide synthase and vasoactive intestinal peptide immunoreactivity in neurons of the major pelvic ganglion projecting to the rat rectum and penis |
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| Authors: | Tokio Domoto Toshiko Tsumori |
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| Institution: | (1) Department of Orthopaedic Surgery, School of Medicine, Yamaguchi University, Ube, Japan;(2) Department of Anatomy, School of Medicine, Yamaguchi University, Ube, Japan;(3) Department of Anatomy, School of Medicine, Yokohama City University, Yokohama, Japan;(4) Department of Anatomy, Yamaguchi University School of Medicine, Kogushi 1144, Ube-shi, Yamaguchi, Japan |
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| Abstract: | We demonstrate the existence of nerve fibers possessing substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactivity in the mouse cervical ventral roots. The distribution of the SP and CGRP fibers was similar, but CGRP fibers were generally more numerous. Both types entered the ventral pia mater or formed hairpin loops, but they did not enter the spinal cord directly through these roots. SP and CGRP fibers in the ventral roots were thin and had many varicosities. We suggest that these SP and CGRP fibers are involved not only in a sensory mechanism, but also in other functions, via the release of SP and CGRP from varicosities in the ventral roots. |
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| Keywords: | Substance P Calcitonin gene related peptide Cervical spinal nerve Immunohistochemistry Primary afferents Mouse (ICR) |
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