Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold |
| |
| Authors: | Dziadulewicz E K Walpole C S Snell C R Wrigglesworth R Hughes G A Beattie D Wood J N Beech M M Coote P R |
| |
| Institution: | Novartis Institute for Medical Sciences, London, UK. ed.dziadulewicz@pharma.novartis.com |
| |
| Abstract: | A beta-turn overlay hypothesis has been used to transform the core scaffold of a selective non-peptide bradykinin B2 receptor antagonist into ligands specifically recognized by the CCK2 or NK1 receptors. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
