| 骨骼的内分泌功能 |
| |
| 作者姓名： | Duan XH Qu XX Chang JR Qi YF Tang CS |
| |
| 作者单位： | 1. 北京大学基础医学院生物活性小分子研究室,北京,100191;北京大学医学部生理学与病理生理学系,北京,100191
2. 北京大学医学部生理学与病理生理学系,北京,100191 |
| |
| 基金项目： | 教育部新世纪人才基金,国家重大基础研究发展规划"973"项目基金 |
| |
| 摘 要： | 既往认为骨骼是支持机体基本结构和参与运动及钙磷代谢的主要器官。近年发现组成骨骼的成骨细胞和破骨细胞能合成和分泌多种骨调节蛋白、生长因子、脂肪因子、炎症因子和心血管活性肽等多种生物活性物质,以旁/自分泌方式调节骨骼系统功能,并能通过血液循环远距分泌的方式,调节机体能量代谢、炎症反应和内分泌稳态等。
|
| 关 键 词： | 骨骼 内分泌 骨调节蛋白 细胞因子 生长因子 |
The endocrine function of the skeleton |
| |
| Duan XH,Qu XX,Chang JR,Qi YF,Tang CS.The endocrine function of the skeleton[J].Progress in Physiological Sciences,2010,41(4):248-255. |
| |
| Authors: | Duan Xiao-Hui Qu Xiao-Xuan Chang Jin-Rui Qi Yong-Fen Tang Chao-Shu |
| |
| Institution: | DUAN Xiao-Hui1,2,QU Xiao-Xuan2,CHANG Jin-Rui2,QI Yong-Fen1,TANG Chao-Shu1,2(1Laboratory of Cardiovascular Bioactive Molecule,School of Basic Medical Sciences,Peking University,Beijing 100191,China,2Department of Physiology and Pathophysiology,Peking University Health Science Center,China) |
| |
| Abstract: | Skeleton has long been recognized as a organ supporting body system and regulating metabolism of calcium and phosphorus.Recent researches found that bone cells,especially osteoblast and osteoclast,synthesize and secrete various bioactive molecules,such as bone morphogenetic proteins,growth factors,adipokines,inflammatory cytokines and cardiovascular bioactive peptides.The active factors produced by bone not only play important roles in the skeleton system per se by paracrine/autocrine pathway but also regul... |
| |
| Keywords: | skeleton endocrine bone regulatory protein cytokines growth factors |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
|
