Ca2+ ionophoretic activity of oligomers of prostaglandin B1 with isolated hepatocytes |
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| Authors: | S Uribe R Villalobos-Molina T M Devlin |
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| Affiliation: | 1. Department of Civil Eng., Faculty of Eng., Urmia University, P O Box 165, Urmia 57561-15311, Iran;2. Department of Civil Eng., Faculty of Eng., Urmia University, P O Box 165, Urmia 57561-15311, Iran;3. Department of Water Eng., University of Zanjan, Zanjan 45371-38791, Iran;1. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;2. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;3. Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, Pennsylvania;4. Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania;5. Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania;8. Department of Psychology, Vanderbilt University, Nashville, Tennessee;6. Department of Radiology, Washington University, St. Louis, Missouri;7. Grossman Center for the Statistics of Mind, Center for Theoretical Neuroscience, Department of Statistics, Columbia University, New York, New York;1. Service de gynécologie obstétrique, hôpital Bicêtre, AP–HP, Le-Kremlin-Bicêtre, France;2. Service de chirurgie pédiatrique, hôpital Bicêtre, AP–HP, Le-Kremlin-Bicêtre, France;3. Service de gynécologie obstétrique, hôpital Antoine-Béclère, AP–HP, Clamart, France;1. Institute of Mechanics, Materials and Civil Engineering, UCLouvain, 1348 Louvain-la-Neuve, Belgium;2. IMDEA Materials Institute, Calle Eric Kandel 2, 28906 Getafe, Madrid, Spain;3. Universidad Politécnica de Madrid, E.T.S. de Ingenieros de Caminos, 28040 Madrid, Spain |
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| Abstract: | Chemically synthesized oligomers (dimers, trimers and tetramers) of 15-dehydroprostaglandin B1 and 16,16'dimethyl-15-dehydroprostaglandin B1 (16,16'diMePGB1) are effective Ca2+ ionophores with isolated mitochondria and in artificial systems. The trimer of 16, 16'diMePGB1 mediated a dose dependent Ca2+ efflux from intact rat hepatocytes; at 9.2 microM oligomer, Ca2+ was released primarily from the mitochondrial pool but at higher concentrations from other cellular pools. The 16, 16'diMePGB1 trimer did not alter Ca2+ release mediated by epinephrine suggesting that the PGB1 oligomer interacts at a different site. The oligomer also caused an activation of phosphorylase similar to that mediated by epinephrine. |
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