The orphan receptor ERRalpha interferes with steroid signaling |
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Authors: | Teyssier Catherine Bianco Stéphanie Lanvin Olivia Vanacker Jean-Marc |
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Affiliation: | Catherine Teyssier, Stéphanie Bianco, Olivia Lanvin, and Jean-Marc Vanacker |
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Abstract: | The estrogen receptor-related receptor α (ERRα) is an orphan member of the nuclear receptor superfamily that has been shown to interfere with the estrogen-signaling pathway. In this report, we demonstrate that ERRα also cross-talks with signaling driven by other steroid hormones. Treatment of human prostatic cells with a specific ERRα inverse agonist reduces the expression of several androgen-responsive genes, in a manner that does not involve perturbation of androgen receptor expression or activity. Furthermore, ERRα activates the expression of androgen response elements (ARE)-containing promoters, such as that of the prostate cancer marker PSA, in an ARE-dependent manner. In addition, promoters containing a steroid response element can be activated by all members of the ERR orphan receptor subfamily, and this, even in the presence of antisteroid compounds. |
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