A size barrier limits protein diffusion at the cell surface to generate lipid-rich myelin-membrane sheets |
| |
Authors: | Aggarwal Shweta Yurlova Larisa Snaidero Nicolas Reetz Christina Frey Steffen Zimmermann Johannes Pähler Gesa Janshoff Andreas Friedrichs Jens Müller Daniel J Goebel Cornelia Simons Mikael |
| |
Institution: | Max-Planck-Institute of Experimental Medicine, 37075 G?ttingen, Germany, University of G?ttingen, 37075 G?ttingen, Germany. |
| |
Abstract: | The insulating layers of myelin membrane wrapped around axons by oligodendrocytes are essential for the rapid conduction of nerve impulses in the central nervous system. To fulfill this function as an electrical insulator, myelin requires a unique lipid and protein composition. Here we show that oligodendrocytes employ a barrier that functions as a physical filter to generate the lipid-rich myelin-membrane sheets. Myelin basic protein (MBP) forms this molecular sieve and restricts the diffusion of proteins with large cytoplasmic domains into myelin. The barrier is generated from MBP molecules that line the entire sheet and is, thus, intimately intertwined with the biogenesis of the polarized cell surface. This system might have evolved in oligodendrocytes in order to generate an anisotropic membrane organization that facilitates the assembly of highly insulating lipid-rich membranes. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|