GFP-expressing influenza A virus for evaluation of the efficacy of antiviral agents |
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Authors: | Kim Jin Il Park Sehee Lee Ilseob Lee Sangmoo Shin Saem Won Yongkwan Hwang Min-Woong Bae Joon-Yong Heo Jun Hyun Hye-Eun Jun Hyejin Lim Soon Sung Park Man-Seong |
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Affiliation: | Department of Microbiology, Hallym University, Chuncheon, 200-702, Republic of Korea. |
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Abstract: | To address its value as a screening tool in the development of antiviral drugs, a recombinant influenza virus expressing green fluorescent protein (rPR8-GFP virus) was investigated in vitro and in vivo. The inhibition of viral growth by a neuraminidase inhibitor in the cells or lower respiratory tracts of mice could be visualized by the level of fluorescence. In addition, the rPR8-GFP virus exhibited high pathogenicity in mice. Taken together, these results suggest that the rPR8-GFP virus can be a useful tool for the rapid identification of antiviral drugs active against influenza viruses. |
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