A new serum lipoprotein found in many rhesus monkeys. |
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Authors: | C A Nelson M D Morris |
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Affiliation: | 1. Department of Biochemistry University of Arkansas for Medical Sciences Little Rock, Arkansas 72201 USA;2. Department of Pediatrics University of Arkansas for Medical Sciences Little Rock, Arkansas 72201 USA |
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Abstract: | A new serum lipoprotein was found in about 10 out of 30 rhesus monkeys () which contained 28% by weight of protein, 42% total cholesterol, 22% phospholipid, and 8% triglyceride. This is in contrast to LDL (which the ten monkeys also contained) which had 24% protein, 46% total cholesterol, 24% phospholipid and 7% triglyceride. An Sf, 1.063 in KBr of 3.0 to 3.7 and molecular weight of 3.5 – 3.7 million were observed compared to means of 8.1 and 3.0 million for normal rhesus LDL. The lower Sf was caused by its higher density. This new lipoprotein was most easily demonstrated and isolated by preparative ultracentrifugation of all serum lipoproteins at density 1.22 g/ml, followed by 6% agarose gel filtration at 6°. The new lipoprotein appeared as a distinct peak eluting before LDL. |
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Keywords: | To whom reprint requests should be submitted. |
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