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Nuclear cGAS: sequestration and beyond |
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| Authors: | Juli Bai Feng Liu |
| Affiliation: | 1.Departments of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX USA ;2.National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 410011 China |
| Abstract: | The cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type Ⅰ interferon and ... |
| Keywords: | cGAS STING innate immunity nuclear translocation DNA damage repair micronuclei |
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