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Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer |
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| Authors: | Bing Liu Daniela Duenas Li Zheng Karen Reckamp Binghui Shen |
| Institution: | 1.Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010 USA ;2.Division of Medical Oncology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, West Hollywood, CA 90048 USA |
| Abstract: | The mutation-mediated overexpression of epidermal growth factor receptor tyrosine kinase (EGFR TK) and its activation play an important role in the cellular pro... |
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