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Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex |
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| Authors: | Yoakim Christiane Ogilvie William W Goudreau Nathalie Naud Julie Haché Bruno O'Meara Jeff A Cordingley Michael G Archambault Jacques White Peter W |
| Affiliation: | Department of Chemistry, Boehringer Ingelheim (Canada) Ltd., 2100 Cunard Street, Laval, Québec, Canada H7S 2G5. cyoakim@lav.boehringer-ingelheim.com |
| Abstract: | We have discovered a series of inhibitors of the assembly of the HPV11 E1-E2-origin DNA complex, which incorporate an indandione fused to a substituted tetrahydrofuran. |
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