Nuclear envelope-limited chromatin sheets (ELCS) and heterochromatin higher order structure |
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Authors: | Donald E Olins Ada L Olins |
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Institution: | (1) Department of Biology, Bowdoin College, 6500 College Station, Brunswick, ME 04011, USA |
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Abstract: | The interphase nucleus and nuclear envelope can acquire a myriad of shapes in normal or pathological cell states. There exist
a wide variety of indentations and invaginations, of protrusions and evaginations. It has been difficult to classify and name
all of these nuclear shapes and, consequently, a barrier to understanding the biochemical and biophysical causes. This review
focuses upon one type of nuclear envelope shape change, named “nuclear envelope-limited chromatin sheets” (ELCS), which appears
to involve exaggerated nuclear envelope growth, carrying with it one or more layers of ∼30 nm diameter heterochromatin. A
hypothesis on the formation of ELCS is proposed, relating higher order heterochromatin structure in an interphase nucleus,
nuclear envelope growth, and nuclear envelope-heterochromatin interactions. |
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Keywords: | |
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