Mechanism underlying silent cleanup of apoptotic cells |
| |
Authors: | Kobayashi Yoshiro |
| |
Affiliation: | Division of Molecular Medicine, Department of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Japan. yoshiro@biomol.sci.toho-u.ac.jp |
| |
Abstract: | Apoptotic cells are cleared without an inflammatory response such as neutrophil infiltration. The mechanism underlying such silent cleanup of apoptotic cells has been intensively investigated in vitro for over a decade, and the concept that active suppression via IL-10, TGF-β, and nitric oxide enables such silent cleanup to occur has been emerging. However, because this concept has not been vigorously examined under a variety of experimental conditions in vivo, the possibility remains that a null response, in which neither cytokines nor nitric oxide is produced upon an encounter with apoptotic cells, is responsible for silent cleanup. |
| |
Keywords: | apoptotic cell anti‐inflammatory cytokine macrophage nitric oxide |
本文献已被 PubMed 等数据库收录! |
|