Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages |
| |
Authors: | Chiu Feng-Lan Lin Jen-Kun |
| |
Affiliation: | Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1 Section 1, Jen-ai Road, Taipei 10018, Taiwan. |
| |
Abstract: | We use the LPS-stimulated macrophage as a model of inflammation to investigate the anti-inflammatory effects of tomatidine and solasodine, whose structures resemble glucocorticoids. We found that tomatidine exhibited a more potent anti-inflammatory effect than solasodine. Tomatidine could decrease inducible nitric oxide synthase and cyclooxygenase-2 expression through suppression of I-kappaBalpha phosphorylation, NF-kappaB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Here, we demonstrate that tomatidine acts as an anti-inflammatory agent by blocking NF-kappaB and JNK signaling, and may possibly be developed as a useful agent for the chemoprevention of cancer or inflammatory diseases. |
| |
Keywords: | Tomatidine iNOS COX-2 NF-κB JNK AP-1 Oct-2 |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|