Effects of cervical-lymphatic blockade on brain edema and infarction volume in cerebral ischemic rats |
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Authors: | Si Jinchao Chen Lianbi Xia Zuoli |
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Institution: | Institute of Physiology, School of Medicine, Shandong University, Jinan 250012, Shandong, P.R.China. |
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Abstract: | To observe the effects of cervical-lymphatic blockade (CLB) on brain edema and infarction volume of ischemic (MCAO) rat, we examined changes in cerebral water content, Ca2+ and glutamate concentrations, cerebral infarction volume and mRNA expression levels of N-methyl-D-aspartame receptor 1 (NMDA receptor 1) in the ischemic (left) hemisphere. The present results demonstrated that all the above indices in rats with middle cerebral artery occlusion plus cervical lymphatic blockade (MCAO+CLB) were markedly higher than those with only middle cerebral artery occlusion (MCAO) at different time points. These results indicated corrected] that CLB can aggravate cerebral ischemia by increasing brain edema and infarction volume. |
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