Combined Haplotypes of CaSR Gene Sequence Variants and Their Associations with Growth Traits in Cattle |
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Authors: | Binglin Yue Fuhai Han Jiyao Wu Yanhuan Wang Chunlei Zhang Xingtang Fang |
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Affiliation: | Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China |
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Abstract: | The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor that regulates food intake and assimilation. However, studies on the relationship between CaSR gene and growth traits in cattle are deficient. The aim of this study was to examine the association of the CaSR polymorphism with growth traits in cattle breeds. Four novel single nucleotide polymorphisms (SNPs) and one previously reported SNP (NC_007299.5: g.67630865T>C, 67638409G>C, 67660395G>C, 67661546C>G, and 67661892A>C) were identified in the bovine CaSR gene using DNA sequencing and PCR-SSCP methods in 520 individuals from three representative breeds. The three SNP P4_2, P7_1, and P7_4 in LX, QC, and JX cattle populations belonged to intermediate genetic diversity (0.25?
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Keywords: | CaSR gene cattle combined haplotype growth traits sequence variants |
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