Protease activity associated with HeLa cell ribosomes |
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Authors: | B D Korant |
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Institution: | Central Research and Development Department E. I. du Pont de Nemours and Company Experimental Station Wilmington, Delaware 19898 USA |
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Abstract: | HeLa cells contain endoprotease activity, detected by a sensitive, solid phase assay. The endoprotease has the ability to cleave a variety of protein substrates and is trypsin-like in its sensitivity to inhibitors. The activity is in part associated with cellular ribosomes and polysomes. A variety of biological and physical-chemical treatments which alter ribosomes or protein synthesis also directly affect the ribosomal protease activity. |
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