<Emphasis Type="SmallCaps">l</Emphasis>-Homoarginine suppresses exocrine pancreas in rats |
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Authors: | T Hira S Ohyama H Hara |
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Institution: | (1) Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo, Japan, JP |
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Abstract: | Summary. Previously, we found that guanidinated casein, a l-homoarginine-containing protein, was a more potent stimulator of pancreatic enzyme secretion than intact casein in rats.
In this study, we examined secretory response and adaptation of the exocrine pancreas to the administration of free l-homoarginine in normal and bile-pancreatic juice (BPJ)-diverted rats. An intraperitoneal injection of l-homoarginine (10 mg/rats) produced immediate and transient reduction in pancreatic secretion in BPJ-diverted rats, but not
in normal rats. The BPJ-diverted rats were fed with either a 25% casein, 45% casein, or 45% casein diet supplemented with
l-homoarginine (19 g/kg diet) for 4 days. Feeding of a diet containing l-homoarginine inhibited the pancreatic adaptation induced by the high-protein diet. These results indicate that l-homoarginine has an inhibitory effect on the secretion and production of exocrine pancreatic enzyme in BPJ-diverted rats,
and l-homoarginine may have an antagonistic effect on CCK receptors.
Received July 1, 2002 Accepted August 28, 2002 Published online December 20, 2002
Authors' address: Dr. Hiroshi Hara, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku,
Sapporo 060-8589, Japan E-mail: hara@chem.agr.hokudai.ac.jp |
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Keywords: | : l-Homoarginine Pancreatic secretion Pancreatic hypertrophy Bile-pancreatic juice diversion Hypercholecystokinemia Rat |
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