Antimelanomal activity of the copper(II) complexes of 1-substituted 5-amino-imidazole ligands against B16F10 mouse melanoma cells |
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| Authors: | Sandbhor Uday Kulkarni Pallavi Padhye Subhash Kundu Gopal Mackenzie Grahame Pritchard Robin |
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| Institution: | Department of Chemistry, University of Pune, Pune 411007, India. sandbhor.1@osu.edu |
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| Abstract: | The copper complexes of 5-amino-imidazole ligands were prepared and characterized by various spectroscopic techniques. The ligand geometry around the copper(II) centre is square pyramidal based on N2O2 donor atoms and a coordinated water molecule at the apex. Single crystal X-ray structures were determined for both ligands. Ligands and copper complexes exhibited dose-dependent antiproliferative effects on the growth of B16F10 melanoma cells line but lower IC50 values were observed for the copper complexes. |
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