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Differential effects of actinomycin D on nucleic acid and protein synthesis in rat liver |
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| Authors: | L Prosky B Roberts R G O'Dell R L Imblum |
| Affiliation: | 1. Interdisciplinary Research Center for Hydrogen & Energy Storage (IRC-HES), King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia;2. Materials Science and Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia;3. Mechanical Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia;4. Department of Buiding and Energy Technology, Linnæus University, SE-351 95 Växjö, Sweden |
| Abstract: | Levels of actinomycin D which block up to 90% of RNA synthesis in liver inhibit protein synthesis by 40%. A 50% inhibition of RNA synthesis is accompanied by less than a 5% inhibition of protein synthesis. These results indicate that the effects of actinomycin D on protein synthesis may be only partially related to the antibiotic effects on RNA synthesis. |
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