Lipase-catalyzed resolution of primary alcohol containing quaternary chiral carbon |
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| Authors: | Chan Seong Cheong Dai Sig Im Jiyoung Kim In O Kim |
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| Institution: | (1) Division of Applied Science, Korea Institute of Science and Technology, #39-1, Hawolkokdong, 136-791 Seongbuk-ku, Seoul, Korea |
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| Abstract: | Summary 2-Cyano-2-phenyl-1-hexanol containing chiral quaternary carbon was resolved using a lipase. Among various reaction conditions, transesterification reaction (solvent; n-hexane, lipase; Candida cylindracea) gave high selectivity(20/80). Additionally, the selectivity could be improved(13/87) when pyridine(1%) was used as an additive. The ratios of resolved alcohols were determined by GC and 1H-NMR analysis using Mosher's derivative. |
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