Phytochemical analysis of <Emphasis Type="Italic">Andrographis paniculata</Emphasis> extract and its antimicrobial activity |
| |
Authors: | Soma Roy Kiranmayee Rao Ch Bhuvaneswari Archana Giri Lakshmi Narasu Mangamoori |
| |
Institution: | (1) Biotechnology Department, Chaitanya Bharathi Institute of Technology, Hyderabad, India;(2) Center for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, 500 085, India |
| |
Abstract: | The present study describes the phytochemical profile and antimicrobial activity of Andrographis paniculata. For the present investigation, two samples of A. paniculata extracts, obtained by extraction in chloroform and chloroform + HCl, respectively, were compared for their antimicrobial
activity and further subjected to GC-MS analysis to find out the nature of the compounds responsible for the antimicrobial
activity. The antibacterial activities were assessed by measuring the diameter of the inhibition zones, MIC and MBC values.
Compared to the chloroform + HCl extract, the chloroform extract showed better antimicrobial activity against all the nine
pathogenic bacterial strains tested. The chloroform extract was observed to be active against the opportunistic and pathogenic
gram-negative bacteria, indicating its potential application related to noscomial infections. GC-MS results revealed phenols,
aromatic carboxylic acids and esters in the chloroform extract to be the molecules responsible for the antimicrobial activity
of A. paniculata. This is the first report on analysis of antimicrobial components from A. paniculata, and our results confer the utility of this plant extract in developing a novel broad spectrum antimicrobial agent. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|